Oral TMP-SMX desensitization protocol

	TMP dose (mg)	SMX dose (mg)	Volume and formulation
Day 1
9 AM	0.8	4	1 mL of 1:10 dilution
11 AM	1.6	8	2 mL of 1:10 dilution
1 PM	4	20	5 mL of 1:10 dilution
5 PM	8	40	10 mL of 1:10 dilution
Day 2
9 AM	16	80	2 mL of undiluted suspension
3 PM	32	160	4 mL of undiluted suspension
9 PM	40	200	5 mL of undiluted suspension
Day 3
9 AM	80	400	One TMP-SMX single-strength tablet

The solution used on day 1 may be prepared from the oral suspension (which contains 40 mg of trimethoprim and 200 mg of sulfamethoxazole per 5 mL) by combining 2 mL of suspension and 18 mL of water.

TMP: trimethoprim; SMX: sulfamethoxazole.

Adapted from: Caumes E, Guermonprez G, Lecompte C, et al. Efficacy and safety of desensitization with sulfamethoxazole and trimethoprim in 48 previously hypersensitive patients infected with human immunodeficiency virus. Arch Dermatol 1997; 133:465. Copyright ©1997 American Medical Association.

Graphic 70864 Version 4.0

خرید پکیج

Oral TMP-SMX desensitization protocol