Version July 2025
| Filler type | Name | Properties | Uses | Duration¶ |
| Hyaluronic acid (HA) | Restylane Restylane-L | Non-animal HA; cross-linked with BDDE | Restylane, Restylane-L: Correction of moderate to severe wrinkles and folds (eg, nasolabial folds) and lip augmentation | 6 months |
| Restylane Lyft | Restylane Lyft: Correction of moderate to severe wrinkles and folds (eg, nasolabial folds), cheek augmentation, and correction of age-related midface contour deficiencies | |||
| Restylane Silk | Restylane Silk: Lip augmentation and correction of perioral wrinkles | |||
| Juvéderm Ultra XC Juvéderm Ultra Plus XC | Non-animal, cross-linked HA; XC formulations contain lidocaine | Juvéderm Ultra, Juvéderm Ultra XC, Juvéderm Ultra Plus, Juvéderm Ultra Plus XC: Correction of moderate to severe wrinkles and folds (eg, nasolabial folds) | 6 to 12 months | |
| Juvéderm Voluma XC | Juvéderm Voluma XC: Correction of volume deficits in the midface | |||
| Juvéderm Volbella XC | Juvéderm Volbella XC: Lip augmentation and correction of perioral rhytides | |||
| Juvéderm Vollure XC | Juvéderm Vollure XC: Moderate to severe facial wrinkles and folds (eg, nasolabial folds) | |||
| Belotero Balance | Non-animal HA; cross-linked with BDDE | Moderate to severe folds or wrinkles, such as the nasolabial folds | 6 months | |
| Elevess | Non-animal HA + lidocaine; cross-linked with BCDI, sodium metabisulfite preservative | Correction of moderate to severe wrinkles and folds (eg, nasolabial folds) | 12 months | |
| Prevelle Silk | Non-animal HA + lidocaine | Correction of moderate to severe wrinkles and folds (eg, nasolabial folds) | 6 months | |
| Teosyal | Non-animal HA, cross-linked with BDDE; reduced protein and bacterial endotoxin level, no lidocaine | Correction of fine lines to deeper rhytides and facial sculpting | 6 to 12 months | |
| Revanesse Ultra | Non-animal HA, cross-linked with BDDE | Correction of moderate to deep rhytides, as well as lipoatrophy and facial wasting | 6 to 12 months | |
| Calcium hydroxylapatite microspheres (CaHA) | Radiesse | Synthetic CaHA microspheres (25-45 mcm) suspended in an aqueous carboxymethylcellulose gel carrier | For correction of moderate-to-severe facial wrinkles and folds (eg, nasolabial folds); for the correction of facial lipoatrophy | 12 months |
| Poly-L-lactic acid (PLLA) | Sculptra | Microparticles of PLLA induce fibroblastic activity; PLLA particles are eventually metabolized | For restoration and/or correction of facial lipoatrophy | 12 to 24 months |
| Sculptra Aesthetic | For correction of shallow to deep nasolabial fold contour deficiencies and other facial wrinkles | |||
| Autologous fat | N/A | Harvesting and reinjection of fat | Dermal/lip augmentation | Months to years |
| Platelet-rich fibrin matrices (PRFM) | SELPHYL System | PRFM generated through collection and centrifugation of blood; stimulates cell proliferation and skin rejuvenation over time | Glabellar lines, nasolabial folds, acne or post-operative scars, full-face contouring, and other dermal defects | 3 months to years |
BDDE: butanediol diglycidyl ether; BCDI: biscarbodiimide.
* This is not a complete list of biodegradeable fillers and primarily reflects agents available in the United States. Collagen-based filling agents are additional biodegradable fillers.
¶ The duration of filler effect tends to be longer in the upper face and mid face than in the perioral region.