Some mechanisms of tumor cell escape from immunologic recognition

T cells

Lack of tumor-specific molecules or peptide presentation

Downregulation of HLA-class I molecules

Lack of costimulation

Functional defects in T cells

NK cells

Appropriate expression of self HLA class I

Soluble inhibitors of NK cell function

Both

Fas ligand expression

Heterogeneity and mutations

Resistance to apoptosis

Tumor_cell_escape.htm

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