Biological agents associated with inflammatory bowel disease

Growth factors	Immunoregulatory cytokines
Platelet-activating factor Keratinocyte growth factor Trefoil peptides Epidermal growth factor	IL-1 receptor antagonist IL-4 IL-5 IL-10 IL-13 IL-22 IL-27 IL-35 TGF-beta
Inflammatory cytokines	Chemokines
IL-1-beta IL-2 IL-6 IL-9 IL-12 IL-17 IL-18 IL-21 IL-23 IL-32 IL-33 TNF-alpha TNFSF15 (TL1A) IFN-gamma	CCL2 CCL20 CCL25 CXCL9 CXCL10 CXCL11 IL-8
Reactive metabolites	Cell adhesion molecules
Reactive oxygen species Nitric oxide	ICAM-1;LFA-1 MAdCAM-1:Alpha4 beta7 VCAM-1:Alpha4 beta1
Arachidonic acid metabolites	Short chain fatty acids

IL: interleukin.

Graphic 71237 Version 6.0