Clinical monitoring for medullary thyroid cancer and timing of thyroidectomy in patients with pathogenic variants in the RET gene

Clinical monitoring for medullary thyroid cancer and timing of thyroidectomy in patients with pathogenic variants in the RET gene

Risk	RET codon mutation	Recommended age to begin annual screening for MTC*	Recommended timing of prophylactic thyroidectomy^¶
Highest	918	Not applicable	In the first months to year of life
High	634, 883	3 years	At or before age 5 years
Moderate	533, 609, 611, 618, 620, 630, 666, 768, 790, 804, 891, 912	5 years	Childhood or young adulthood

Risk of MTC development in MEN2 depends on mutated RET codon.

MTC: medullary thyroid cancer; MEN2: multiple endocrine neoplasia type 2.

* Annual physical examination, neck ultrasound, and measurement of serum calcitonin.

¶ Patients with MEN2 and a diagnosis of MTC (regardless of age) must have pheochromocytoma excluded prior to thyroidectomy.

Data from: Wells SA Jr, Asa SL, Dralle H, et al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid 2015; 25:567.

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خرید پکیج

Clinical monitoring for medullary thyroid cancer and timing of thyroidectomy in patients with pathogenic variants in the RET gene