Medications associated with diarrhea

System targeted by drug	Type of agent	Examples
Cardiovascular	Antiarrhythmics	Digoxin Procainamide Quinidine
	Antihypertensives	ACE inhibitors Angiotensin II receptor blockers* Beta blockers Hydralazine Methyldopa
	Cholesterol-lowering agents	Clofibrate Gemfibrozil Statins
	Diuretics	Acetazolamide Ethacrynic acid Furosemide
Central nervous system	Antianxiety drugs	Alprazolam Meprobamate
	Antiparkinsonian drugs	Levodopa
	Other agents	Anticholinergic agents Fluoxetine Lithium Tacrine
Endocrine	Oral hypoglycemic agents	Metformin
Endocrine	Thyroid replacement therapy	Synthroid
Gastrointestinal	Antiulcer/antacid drugs	H2RAs Magnesium-containing antacids Misoprostol Proton pump inhibitors
	Bile acids	Chenodeoxycholic acid Ursodeoxycholic acid
	Laxatives	Cathartics Lactulose Sorbitol
	Treatments for inflammatory bowel disease	5-aminosalycilates (particularly olsalazine)
Musculoskeletal	Gold salts	Auranofin
	Nonsteroidal antiinflammatory drugs	Ibuprofen Mefenamic acid Naproxen Phenylbutazone
	Treatments for periodic fever syndrome or gout	Colchicine
Other	Antibiotics^¶	Amoxicillin Ampicillin Cephalosporins Clindamycin Neomycin Tetracycline
	Antineoplastic agents	Many
	Dietary	Alcohol Sugar substitutes (eg, sorbitol)
	Vitamins	Magnesium Vitamin C

ACE: angiotensin-converting enzyme; H2RA: histamine-2 receptor antagonist.
* Olmesartan has been associated with sprue-like enteropathy.
¶ Most antibiotics have been associated with diarrhea.

Data from:

Holt PR. Diarrhea and malabsorption in the elderly. Gastroenterol Clin North Am 2001; 30:427.
Ratnaike RN, Jones TE. Mechanisms of drug-induced diarrhoea in the elderly. Drugs Aging 1998; 13:245.

Graphic 71449 Version 7.0

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Medications associated with diarrhea