Adhesion molecules in leukocyte migration

Adhesion molecule	Cellular expression for leukocyte migration
Integrins
LFA-1 (CD11a/CD18b)	Present on lymphocytes
Mac-1 (CR3, CD11b/CD18b)	Present on neutrophils and monocytes
gp 150/95 (CD11c/CD18b)	Present on neutrophils and monocytes
VLA-4	Present on lymphocytes, monocytes, and eosinophils
Immunoglobulin superfamily
ICAM-1	Low-level constitutive endothelial cell expression
ICAM-1	Increased endothelial cell expression with stimulation
ICAM-2	High-level constitutive endothelial cell expression
ICAM-2	No increase with stimulation
VCAM-1	No constitutive endothelial cell expression
VCAM-1	Increased endothelial cell expression with stimulation
Selectins
P-selectin	Platelet and endothelial cell surface expression after stimulation
E-selectin	Exclusively expressed on stimulated endothelial cells
L-selectin	Constitutively expressed on neutrophils, monocytes, and a T cell subset
L-selectin	Shed from neutrophils after stimulation with chemoattractants

LFA: lymphocyte function-associated antigen; CD: cluster of differentiation; Mac: macrophage antigen; CR: complement receptor; gp: glycoprotein; VLA: very late antigen; ICAM: intracellular adhesion molecule; VCAM: vascular cell adhesion molecule.

Graphic 71824 Version 5.0

خرید پکیج

Adhesion molecules in leukocyte migration