Depiction of interdependence of sensitivity and specificity

The curves represent serum aminotransferase levels for populations with and without chronic hepatitis. As the cutoff used for defining an abnormal value (dashed blue line) is moved toward the right, more patients with hepatitis will be missed (loss of sensitivity). As the dashed blue line is moved to the left, more patients without hepatitis will be incorrectly labeled as having hepatitis (loss of specificity).