Biologic effects of proinflammatory cytokines such as TNF and IL-1

Fever

Hypotension

Acute phase protein response

Induction of IL-6 and IL-8

Coagulation activation

Fibrinolytic activation

Leukocytosis

Neutrophil degranulation and augmented antigen expression (TNF)

Increased endothelial permeability (TNF)

Stress hormone response

Enhanced gluconeogenesis (TNF)

Enhanced lipolysis (TNF)

Effects_of_cytokines.htm

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