The fold increase in platelet count on day 14 is shown here versus the logarithm of the administered dose of thrombopoietin. The platelet counts returned to baseline values upon discontinuation of therapy. There was a log-linear dose response of the maximal platelet count.
Adapted from: Harker LA, Marzec UM, Hunt P, et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996; 88:511.
