Factors associated with increased risk for local recurrence and metastasis of cutaneous squamous cell carcinoma

Tumor factors	Rate of recurrence (percent)	Rate of metastasis (percent)
Location
Lip	2.3 to 22.2	3 to 20
Ear	5.3 to 18.7	8.8 to 11.6
Anogenital	14 to 15	15 to 74
Chronic wound or scar	N/A	26.2 to 37.9
Irradiated skin	N/A	20 to 26
Size
≥2 cm	15.2	5.8 to 42.5
Depth
>4 mm/Clark IV, V	17.2	30.4 to 51
>6 mm	N/A	15.6
Recurrent tumor	10 to 27.5	16.3 to 30.3
Poorly differentiated histology	28.6	32.8 to 57.9
Perineural invasion	16 to 47.2	10 to 50
Host factors	Rate of recurrence (percent)	Rate of metastasis (percent)
CLL and SLL	25 to 100	18 to 100
Organ transplantation	10 to 54	6 to 31

CLL: chronic lymphocytic leukemia; SLL: small lymphocytic lymphoma.

From: Ross AS, Schmults CD. Sentinel lymph node biopsy in cutaneous squamous cell carcinoma: A systemic review of the English literature. Dermatol Surg 2006; 32:1309. DOI: 10.1111/j.1524-4725.2006.32300.x. Reproduced with permission from Lippincott Williams & Wilkins. Copyright © 2006 American Society for Dermatologic Surgery. Unauthorized reproduction of this material is prohibited.

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Factors associated with increased risk for local recurrence and metastasis of cutaneous squamous cell carcinoma