Structure model of the TSH receptor

Stimulating (in Graves' disease) and blocking (in Hashimoto's thyroiditis) anti-TSH receptor antibodies may bind to different regions of the ECD.

ECD: extracellular domain; TSH: thyroid-stimulating hormone.

Structure model created using VMD: Humphrey W, Dalke A, Schulten K. VMD: visual molecular dynamics. J Mol Graph 1996; 14:33. Reproduced with permission from Mihaly Mezei, PhD.

Graphic 72949 Version 4.0