NCI CTCAE v5.0 palmar-plantar erythrodysesthesia syndrome

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Palmar-plantar erythrodysesthesia syndrome	Minimal skin changes or dermatitis (eg, erythema, edema, or hyperkeratosis) without pain	Skin changes (eg, peeling, blisters, bleeding, edema, or hyperkeratosis) with pain, limiting instrumental ADL*	Severe skin changes (eg, peeling, blisters, bleeding, edema, or hyperkeratosis) with pain, limiting self-care ADL*

Palmar-plantar erythrodysesthesia syndrome is characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet. Palmar-plantar erythrodysesthesia syndrome is also called hand-foot syndrome. Refer to UpToDate topics on the cutaneous side effects of conventional and molecularly targeted chemotherapy agents for discussion of palmar-plantar dysesthesia syndrome, hand-foot syndrome, and hand-foot skin reaction.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; ADL: activities of daily living.
* Instrumental ADLs include preparing meals, shopping, using the telephone, managing money. Self-care ADLs include bathing, dressing/undressing, using the toilet, taking medications, and not bedridden.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

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NCI CTCAE v5.0 palmar-plantar erythrodysesthesia syndrome