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Differentiation of generalized tonic-clonic seizures from pseudoseizures and syncope

Differentiation of generalized tonic-clonic seizures from pseudoseizures and syncope
Characteristic Generalized seizure tonic-clonic Pseudoseizure Syncope
Circumstances
Situation Awake or sleep Awake Usually upright; any position if cardiogenic
Precipitating factors Sleep loss, alcohol withdrawal, flashing lights Emotion Emotion, injury, heat, crowds; none if cardiogenic
Presence of others Variable Usual Variable
Motor phenomena
Vocalization At onset, if any During course None
Location of motor component (if present) Proximal limb Proximal limb None
Generalized motor Tonic, then clonic Tonic; flailing; struggling or thrashing, or both Usually atonic; if syncope lasts >20 seconds: tonic, then clonic
Tonic posture Partial flexion or straight Opisthotonic -
Head movements To one side or none Side to side -
Clonus/limb jerks Bilaterally synchronous Asynchronous Bilaterally synchronous
Purposeful movements Absent Occasional, including avoidance Absent
Biting Tongue, inside mouth Lips, arms, other people Tongue biting rare
Babinski's sign Present Absent Absent
Autonomic features
Micturition Frequent Rare Occasional
Eyes Open Closed Open
Pupils Dilated or hippus during attacks Normal Dilated
Colour Cyanotic or grey Rubor or normal Pale
Pulse Rapid, strong Normal Slow if vasovagal, weak if vasodepressor; that of arrhythmias if cardiogenic
Timing
Usual duration 1 to 5 min 5 to 60 min 1 to 2 min
Onset Sudden Gradual Gradual; possibly sudden if cardiogenic
Sequence of symptoms Stereotyped Variable Stereotyped
Termination Spontaneous Spontaneous or induced by supraorbital pressure, suggestion Rapid
Sequelae
Injury Frequent, mild; scalp, face, common Rare, but multiple bruises possible; scalp, face, rare If sudden onset
Postictal Tired, confused, sleepy Alert, emotional outburst Regains consciousness in 2 to 3 min; alert but tired
Reproduced with permission from: Blume WT. Diagnosis and management of epilepsy. CMAJ 2003; 168:441. Copyright © 2003 Canadian Medical Association.
Graphic 73515 Version 2.0

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