Drugs that can induce Brugada-like patterns on the surface electrocardiogram (ECG)

Antiarrhythmic or antianginal drugs

Cardiac sodium channel blockers (some have been used for drug challenge in patients with Brugada type 2 or 3 ECG pattern)

Class IC drugs (flecainide, pilsicainide, propafenone)

Class IA drugs (ajmaline, procainamide, disopyramide, cibenzoline)

Lithium

Calcium channel blockers

Beta blockers

Nitrates

Nicorandil (a potassium channel opener)

Psychotropic drugs

Tricyclic antidepressants

Amitriptyline

Nortriptyline

Desipramine

Clomipramine

Tetracyclic antidepressants

Maprotiline

Phenothiazines

Perphenazine

Cyamemazine

Selective serotonin reuptake inhibitors

Fluoxetine

Other

Dimenhydrinate

Cocaine intoxication

Alcohol intoxication

Adapted from: Antzelevitch C, Brugada P, Borggrefe M, et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005; 111:659.

Graphic 73611 Version 5.0

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Drugs that can induce Brugada-like patterns on the surface electrocardiogram (ECG)