Stages of morphea on skin biopsy

Left panel: Skin biopsy from an early stage of morphea showing a mononuclear infiltrate in the interstitium and hyalinization and widening of occasional collagen bundles.
Right panel: Burnt out stage of morphea. The dermal collagen bundles are widened with loss of their fibrillar architecture. There is only a sparse plasma cell rich infiltrate in the interstitium.