ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -28 مورد

Major causes of primary ovarian insufficiency (premature ovarian failure) in females

Major causes of primary ovarian insufficiency (premature ovarian failure) in females
Accelerated follicular atresia
Genetic defects
  • Karyotype abnormalities (X chromosome deletions and translocations including Turner syndrome)
  • Autosomal gene mutations affecting meiosis, transcription, or translation
  • Autosomal gene mutations affecting metabolism (galactosemia, mitochondrial function)
  • Repeat expansion disorders (FMR1)
Ovarian toxins
  • Chemotherapeutic drugs (especially alkylating agents)
  • Radiation
  • Mumps or cytomegalovirus infection
Autoimmune injury
  • Isolated or part of polyglandular autoimmune syndromes
Abnormal follicular stimulation
Intraovarian modulators
  • BMP15
Steroidogenic enzyme defects
  • CYP17 deficiency, StAR mutation
  • Aromatase gene mutations
Gonadotropin receptor function
  • FSH receptor mutations
  • Gs alpha subunit gene mutations
  • Gonad and adrenal development – NR5A1
FSH: follicle-stimulating hormone.
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