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Examples of precaution requirements after treatments with 131-I: Thyroid carcinoma/remnant ablation*

Examples of precaution requirements after treatments with 131-I: Thyroid carcinoma/remnant ablation*
  mCi (MBq) administered
50
(1850)
100
(3700)
150
(5550)
200
(7400)
Restricted periods
Nighttime restrictions
Sleep in a separate (6-feet separation) bed from adults for days shown 1 1 2 4
Sleep in a separate bed from pregnant partners, infant, or child for days shown 6 13 18 21
Daytime restrictions
You may return to work after days shown 1 1 1 1
Maximize your distance (6 feet) from children and pregnant persons for days shown 1 1 1 1
Avoid extended time in public places for days shown 1 1 1 1
Duration of safe travel by public transportation (bus, air, etc)Δ
Travel time (hours) without exceeding regulatory dose limit
Day 0 (beginning with treatment) 1.2 0.6 0.4 0.3
Day 1 3.0 1.5 1.0 0.8
Day 2 7.2 3.8 2.5 1.9
Day 3 15.0 7.5 5.0 3.8
Day 4 15.0 10.0 7.5
Examples should be modified to meet local and specific patient needs. These examples are based on dose rate of 0.17 mrem h–1 mCi–1 at 1 m, 500 mrem per year for family member and caregiver, 100 mrem for pregnant persons, children, and the public, and occupancy factors for adults of 0.25 except for sleeping 0.33. Resumption of sleeping with a partner assumes a distance of 0.3 m.

131-I: radioiodine.

* Assumes that disappearance of 131I is biexponential with early effective T1/2 of about 0.76 days, and 2% uptake in remnant with effective T1/2 of about 7.3 days. Consider formal dosimetry for larger administered doses given to patients with functioning carcinoma. 131I kinetics in euthyroid patients stimulated by recombinant human thyrotropin may differ from those used here.

¶ Day = 24-hour cycle.

Δ Assumes 100 mrem limit and 0.3 m distance.
Reproduced with permission from: The American Thyroid Association Taskforce on Radioiodine Safety. Radiation Safety in the Treatment of Patients with Thyroid Diseases by Radioiodine 131-I: Practice Recommendations of the American Thyroid Association. Thyroid 2011; 21:335. Copyright © 2011 Mary Ann Liebert Publishers.
Graphic 74127 Version 5.0

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