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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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International Society on Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation

International Society on Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation
  1. Risk assessment – Does the patient have an underlying disorder known to be associated with overt DIC?*
  • If yes, proceed
  • If no, do not use this scoring system
  1. Obtain the following laboratory tests
  • Platelet count
  • Fibrin-related markers (eg, FDPs, soluble fibrin monomers, D-dimer)
  • PT
  • Fibrinogen
  1. Assign score for each laboratory parameter
 Score
Platelet count (per microL):
  • >100,000
 0
  • 50,000 to 100,000
 1
  • <50,000
 2
Fibrin-related markers (eg, FDPs, D-dimer):
  • No increase
 0
  • Moderate increase
 2
  • Strong increase
 3
PT:
  • Prolonged <3 seconds
 0
  • Prolonged 3 to 6 seconds
 1
  • Prolonged >6 seconds
 2
Fibrinogen level:
  • >100 mg/dL (>1.0 g/L)
 0
  • <100 mg/dL (<1.0 g/L)
 1
  1. Calculate total score – Add individual scores for each laboratory parameter
  1. Score interpretation:
  • ≥5 – Compatible with overt DIC. Repeat scoring daily.
  • <5 – Suggestive (not affirmative) for non-overt DIC. Repeat in 1 to 2 days.
DIC: disseminated intravascular coagulation; FDPs: fibrin degradation products; PT: prothrombin time.
* Causes of DIC in children include infection, trauma, burns, malignancy, acute and chronic liver disease (including Reye syndrome), microangiopathic disorders (eg, Kasabach-Merritt syndrome), and congenital thrombotic disorders (eg, homozygous deficiencies of protein C and S, antithrombin III deficiency). Additional causes in neonates include birth asphyxia, respiratory distress syndrome, meconium aspiration, amniotic fluid aspiration, and necrotizing enterocolitis.
¶ Although D-dimer is not explicitly included in this scoring system, elevated D-dimer is a strong indicator of fibrinolysis and is more specific than FDPs.
Reproduced with permission from: Taylor FB, Toh CH, Hoots WK, et al. Towards definition, Clinical and Laboratory Criteria, and a Scoring System for Disseminated Intravascular Coagulation. Thromb Haemost 2001; 86:1327. Copyright © 2001 Schattauer GmbH.
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