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Reassessment of the patient with neutropenic fever after two to four days of empiric therapy

Reassessment of the patient with neutropenic fever after two to four days of empiric therapy
ANC: absolute neutrophil count; CT: computed tomography; IV: intravenous; MRI: magnetic resonance imaging.
* We consider patients to be high-risk if they have either of the following characteristics: neutropenia (ANC <500 cells/microL following cytotoxic chemotherapy) anticipated to last >7 days OR significant comorbid conditions. It should be noted that in the Infectious Diseases Society of America guidelines, an ANC ≤100 cells/microL is used as the cutoff for high-risk neutropenia.
Δ Fever in a neutropenic patient is defined as a single temperature >38.3°C (101°F) or a sustained temperature >38.0°C (100.4°F) for >1 hour.
Adapted with permission from: Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the Infectious Diseases Society of America. Clin Infect Dis 2011; 52(4):e56-93. Copyright © 2011 Oxford University Press. Available at: www.idsociety.org.
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