Cardiac ineligibility criteria in the NSABP B-31 and NCCTG N9831 adjuvant trastuzumab trials

Angina pectoris requiring antianginal medication

Arrhythmia requiring medication

Severe conduction abnormality

Clinically significant valvular heart disease

Cardiomegaly on chest radiography

Left ventricular hypertrophy on echocardiogram (NSABP B-31 only)

Poorly controlled hypertension

Clinically significant pericardial effusion (NCCTG trial N9831 only)

History of myocardial infarction, heart failure, or cardiomyopathy

Left ventricular ejection fraction below the lower limit of normal

NSABP: National Surgical Adjuvant Breast and Bowel Project; NCCTG: North Central Cancer Treatment Group.

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