Cutaneous reactions associated with small molecule kinase inhibitors

Drugs	Reported cutaneous effects
Imatinib	Edema, hair repigmentation, hypopigmentation, lichenoid eruption, morbilliform eruption, photosensitization, exacerbation of psoriasis, pruritus, Stevens-Johnson syndrome, xerosis
Dasatinib	Acne, HFSR, alopecia, hyperhidrosis, morbilliform eruption, pruritus, urticaria, xerosis, stomatitis
Nilotinib	Alopecia, morbilliform eruption, pruritus, xerosis
Bosutinib	Acne, allergic dermatitis, erythema, folliculitis, maculopapular rash, pruritic rash, skin exfoliation
Sorafenib	HFSR, edema, flushing, stomatitis (mucositis), subungual splinter hemorrhages, squamous hyperproliferation
Sunitinib	HFSR, bullous dermatosis, edema, hair depigmentation, yellow skin discoloration, stomatitis (mucositis), periungual erythema, subungual splinter hemorrhages
Pazopanib	Change in hair color, skin hypopigmentation, alopecia, rash, HFSR
Vandetanib	Rash, acne, dry skin, dermatitis, pruritus, photosensitivity, HFSR
Regorafenib	HFSR, rash, desquamation
Ponatinib	Rash, acneiform eruption, dry skin
Cabozantinib	HFSR, stomatitis, dry mouth, hair color changes, alopecia
Vemurafenib	Rash, photosensitivity, squamous cell carcinoma, keratoacanthoma, alopecia, radiation enhancement
Dabrafenib	Verrucal keratotic lesions, keratoacanthoma, squamous cell carcinoma, rash, alopecia, structural hair changes
Trametinib	Acneiform eruption, pruritus, xerosis
Axitinib	HFSR, rash, cutaneous vasculopathy
Osimertinib	Maculopapular rash, acneiform eruption, xerosis, nail disease, pruritus

HFSR: hand-foot skin reaction.

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