Version June 2024
| Safety concern | Reason for contraindication and recommended action |
| Previous anaphylactic reaction to a specific vaccine | Avoid revaccination with the specific vaccine because of risk of recurrence. |
| Previous anaphylactic reaction to neomycin or streptomycin | Avoid measles, mumps, rubella (MMR) vaccine because the MMR vaccine contains trace amounts of neomycin. |
| History of severe systemic reactions to the cholera, typhoid or plague vaccine | Avoid revaccination with the specific vaccine because of risk of recurrence. |
| Adults who are immunocompromised as a result of disease or its treatment | Avoid live virus vaccines because there is an increased risk of viral replication in immunocompromised individual. (Refer to UpToDate topics on immunizations in patients with cancer and transplant recipients.) |
| Household members of immunocompromised patients | Avoid oral polio because vaccine induced disease (if it occurs) could be transmitted to the immunocompromised individual. This concern does not apply to the MMR vaccine because infection with vaccine strain measles, mumps or rubella is not transmitted to others. (Refer to UpToDate topic on polio vaccination.) |
| Pregnant women | Avoid all live virus vaccines because of the potential risk to the fetus. (Refer to UpToDate topic on immunizations during pregnancy.) |
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