Gender-affirming hormone treatment with masculinizing effects

Effect	Onset	Maximum
Skin oiliness/acne	1 to 6 months	1 to 2 years
Facial/body hair growth	6 to 12 months	4 to 5 years
Scalp hair loss	6 to 12 months	—*
Increased muscle mass/strength	6 to 12 months	2 to 5 years
Fat redistribution	1 to 6 months	2 to 5 years
Cessation of menses	1 to 6 months	—^¶
Clitoral enlargement	1 to 6 months	1 to 2 years
Vaginal atrophy	1 to 6 months	1 to 2 years
Deepening of voice	6 to 12 months	1 to 2 years

* Prevention and treatment as recommended for biological men.

¶ Menorrhagia requires diagnosis and treatment by a gynecologist.

Reproduced from: Hembree W, Cohen-Kettenis P, Gooren L. Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2017; 102(11):3869-3903. By permission of Oxford University Press on behalf of the Endocrine Society. Copyright © 2017 Oxford University Press. Available at: https://www.endocrine.org/guidelines-and-clinical-practice/clinical-practice-guidelines/gender-dysphoria-gender-incongruence.

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