17-hydroxy-pregnenolone (ng/dL) | 17-hydroxy-progesterone (ng/dL)¶ | 11-deoxy-cortisol (ng/dL) | Cortisol (microgram/dL) | DHEAS (microgram/dL) | DHEA (ng/dL) | Androstenedione (ng/dL) | Testosterone (ng/dL) | |
Baseline (8:00 AM) | ||||||||
Children, 1 to 5 years old | 10-105 | 5-115 | 20-160 | 3-20 | 5-35 | 20-130 | 10-50 | <20 |
Children, 6 to 10 years old | 10-200 | 5-115 | 20-160 | 3-20 | 10-115 | 20-345 | 10-75 | <20 |
Premature adrenarche | 20-350 | 5-200 | 20-160 | 3-20 | 40-130 | 50-600 | 20-75 | 10-35 |
Early pubertal girls | 35-350 | 15-200 | 20-160 | 3-20 | 35-130 | 40-600 | 40-175 | 10-35 |
Adult females, follicular phaseΔ | 55-360 | 15-200 | 20-160 | 3-20 | 75-255 | 100-850 | 60-200 | 20-60 |
After ACTH1-24 (cosyntropin); values are measured 30 to 60 minutes after ≥10 microgram/m2 IV | ||||||||
Children, 1 to 5 years old | 45-350 | 50-335 | 95-300 | 17-45 | 5-35 | 25-100 | 15-70 | <20 |
Children, 6 to 10 years old | 60-650 | 85-335 | 95-300 | 17-45 | 10-115 | 70-320 | 25-100 | <20 |
Premature adrenarche | 80-750 | 85-335 | 95-300 | 17-45 | 40-130 | 80-725 | 25-230 | 10-35 |
Early pubertal girls | 150-750 | 90-335 | 95-300 | 17-45 | 35-130 | 70-725 | 55-230 | 10-35 |
Adult females, follicular phase | 150-1070 | 35-335 | 95-300 | 17-45 | 75-255 | 250-1470 | 60-250 | 20-60 |
Conversion multipliers to SI units | 0.0316 (nmol/L) | 0.0303 (nmol/L) | 0.0289 (nmol/L) | 0.0276 (micromol/L) | 0.0271 (micromol/L) | 0.0347 (nmol/L) | 0.0349 (nmol/L) | 0.0347 (nmol/L) |
DHEA: dehydroepiandrosterone; DHEAS: dehydroepiandrosterone sulfate; IV: intravenously; SI units: International System of Units; LC-MSMS: liquid chromatography-tandem mass spectrometry.
* Values are from a standard specialty laboratory reference (2020) using radioimmunoassay after preparatory chromatography, except cortisol and DHEAS, which were measured by direct immunoassay. Values differ slightly among laboratories. These values generally agree with those by LC-MSMS methodology, except LC-MSMS yields DHEAS values approximately 55% lower[1].
¶ Normal women who are heterozygous for 21-hydroxylase deficiency often have 17-hydroxyprogesterone responses to ACTH greater than those shown. This genotype is present in approximately 2% of women[2].
Δ 17-hydroxyprogesterone begins rising in the preovulatory phase and peaks as high as 400 ng/dL in the luteal phase of the cycle.Modified with permission from: Rosenfield R. Clinical review: Identifying children at risk for polycystic ovary syndrome. J Endocrinol Metab 2007; 92:787. http://jcem.endojournals.org/. Copyright © 2007 The Endocrine Society.
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