Mediation of thyroid hormone action

Binding of T3 disrupts binding of CoR to the TR-RXR heterodimer, promotes binding of CoA, and increases mRNA expression.

CoA: co-activator; CoR: co-repressor; RXR: retinoid X receptor; T3: triiodothyronine; TR: thyroid hormone receptor; TRE: thyroid hormone response element.

Modified from: Refetoff S, Weiss RE. Resistance to thyroid hormone. In: Molecular Genetics of Endocrine Disorders, Thakker TV (Ed), Chapman & Hill, London, 1997, p.89.