Glucocorticoid response element (GRE) binding in asthma

Effect of dexamethasone (1 µM) on glucocorticoid receptor binding to specific consensus dsDNA binding sequences for GRE in nuclear extracts obtained from peripheral blood mononuclear cells from steroid-sensitive (SS, n=6) and steroid-resistant (SR, n=7) asthmatic patients and from normal subjects (Normal, n=3). Mean values are shown at different times after addition of dexamethasone to the cells.