Counterregulatory response to hypoglycemia

Condition	Glucose	Insulin	Glucagon	Epinephrine	Autonomic symptom response
No diabetes	↓	Decreases	Increases	Increases	Activated
T1DM	↓	No decrease*	No increase*	Attenuated increase*^¶	Attenuated activation or absent^¶
T2DM
Early	↓	Decreases	Increases	Increases	Activated
Late (absolute endogenous insulin deficiency)	↓	No decrease*	No increase*	Attenuated increase*^¶	Attenuated activation or absent^¶

Iatrogenic hypoglycemia is the result of the interplay of absolute or relative therapeutic insulin excess and compromised physiologic and behavioral defenses against falling plasma glucose concentrations in type 1 diabetes mellitus (T1DM) and advanced type 2 diabetes mellitus (T2DM).

* Defective glucose counterregulation.

¶ Hypoglycemia unawareness.

Courtesy of Dr. Philip Cryer.

Graphic 75618 Version 4.0

خرید پکیج

Counterregulatory response to hypoglycemia