Version May 2024
| Clinical manifestation | Frequency | Typical time of onset | Course |
| Manifestations in infancy | |||
| Hearing loss | 60% | Early infancy | Permanent |
| Heart defect | 45% | ||
| Patent ductus arteriosus | 20% | Early infancy | Permanent |
| Peripheral pulmonic stenosis* | 12% | Early infancy | Permanent |
| Microcephaly | 27% | Neonatal | Permanent |
| Cataracts | 25% | Early infancy | Permanent |
| Low birth weight (<2500 g) | 23% | Neonatal | Poor weight gain may persist |
| Hepatosplenomegaly | 19% | Neonatal | Transient |
| Purpura | 17% | Neonatal | Transient |
| Developmental delay | 13% | Variable | Permanent |
| Meningoencephalitis | 10% | Neonatal | Transient |
| Radiolucent bone lesions | 7% | Neonatal | Transient |
| Retinopathy | 5% | Early infancy | Permanent |
| Late-onset manifestations¶ | |||
| Hearing loss | Permanent | ||
| Intellectual disability | Permanent | ||
| Diabetes mellitus | Permanent | ||
| Thyroid dysfunctionΔ | Permanent | ||
| Progressive panencephalitis | Permanent | ||
* Includes pulmonary arterial hypoplasia, supravalvular stenosis, valvular stenosis, and peripheral branch stenosis.
¶ The frequency of these manifestations is not known, given the difficulty of establishing a diagnosis of congenital rubella infection in individuals older than 1 year of age.
Δ Includes hyperthyroidism, hypothyroidism, and thyroiditis.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
