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Inflammatory markers that have been studied in CKD patients

Inflammatory markers that have been studied in CKD patients
Category Marker (and commonly used abbreviation) Evidence for outcome predictability in CKD*
Short pentraxins C-reactive protein (CRP) ++++
Serum amyloid P (SAP) ++
Long pentraxins Pentraxin-3 (PTX3) ++
Neuronal pentraxins ?
Pro-inflammatory cytokines Interleukin-6 (IL-6) ++++
Interleukin-1 beta (IL-1-beta) +
Tumor necrosis factor alpha (TNF-alpha) +/-
Interleukin-8 (IL-8) +
Interleukin-18 (IL-18) ?
Interleukin-12 (IL-12) ?
Interferon gamma (IFN-gamma) +
Anti-inflammatory cytokines Interleukin-10 (IL-10) ?
IL-1 receptor antagonist (IL-1ra) +
Interleukin-4 (IL-4) ?
Transforming growth factor beta (TGF-beta) ?
Adipokines and related compounds Adiponectin ++
Visfatin +
Resistin +
Leptin +
CD163 +
Adhesion molecules and endothelial markers Intercellular adhesion molecule-1 (ICAM-1) ++
Vascular cell adhesion molecule-1 (VCAM-1) ++
E-selectin +
Coagulation markers Fibrinogen +
Tissue plasminogen activator (t-PA) +
Plasminogen activator inhibitor-1 [PAI-1]) +
von Willebrand factor (vWF) & factor VII ?
Fibrin D-dimer ?
Inflammatory molecules with negative acute phase reaction Albumin (negative) ++++
Transferrin or TIBC ++
Iron ++
Fetuin +
Inflammatory lipoproteins HDL inflammatory index (HII) ++
Oxidized LDL (oxLDL) +
Inflammatory enzymes Myeloperoxidase (MPO) +
Matrix metalloproteinase (MMP-9) +
Pro-inflammatory transcription factors Activator protein-1 (AP-1) +
Nuclear factor-kappa B (NF-κB) +
Other inflammatory markers Serum ferritin +++
Serum amyloid A (SAA) +
Neopterin (monocyte/macrophage activator) +
Platelet count +++
WBC count ++
Neutrophil count +
Erythrocyte sedimentation rate (ESR) +
CKD: chronic kidney disease; WBC: white blood cell.
* Evidence for CKD outcome predictability pertains to CKD progression or patient survival.
Reproduced with permission from: Kalantar-Zadeh K. Inflammatory marker mania in chronic kidney disease: pentraxins at the crossroad of universal soldiers of inflammation. Clin J Am Soc Nephrol 2007; 2:872. Copyright ©2007 American Society of Nephrology.
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