Clinical manifestations of relapsing polychondritis

Clinical manifestation	Present at disease onset (percentage)	Cumulative presence over disease course (percentage)
Auricular chondritis	43	89
Arthritis	32	72
Nasal chondritis	21	61
Ocular inflammation	18	59
Laryngotracheal symptoms	23	55
Reduced hearing	7	40
Vestibular dysfunction*	4	28
Microhematuria^¶	15	26
Saddle nose*	11	25
Cutaneous*	4	25
Laryngotracheal stricture^¶	15	23
Vasculitis*	2	14
Elevated creatinine^¶	7	13
Aortic or mitral regurgitation*	0	12
Aneurysm^¶	0	4

Data derived from three large case series and reviews, totaling 337 patients^[1-3].

* Data incomplete or not reported in the study by McAdam et al^[1].
¶ Data only from the study by Michet et al^[2].

References:

McAdam LP, O'Hanlan MA, Bluestone R, et al. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore) 1976; 55:193.
Michet CJ Jr, McKenna CH, Luthra HS, et al. Relapsing polychondritis: Survival and predictive role of early disease manifestations. Ann Intern Med 1986; 104:74.
Trentham DE, Le CH. Relapsing polychondritis. Ann Intern Med 1998; 129:114.

Reproduced with permission from: Kent PD, Michet CJ, Luthra HS. Relapsing polychondritis. Curr Opin Rheumatol 2004; 16:56. Copyright © 2004 Lippincott Williams & Wilkins. Unauthorized reproduction of this material is prohibited.

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Clinical manifestations of relapsing polychondritis