Version June 2024
| One point is given for each of the characteristics below present in the patient, for a total score ranging from zero to seven | ||
| Serum albumin <4 g/dL | ||
| Hemoglobin <10.5 g/dL | ||
| Male gender | ||
| Age >45 years | ||
| Stage IV disease | ||
| White blood cell count ≥15,000/microL | ||
| Absolute lymphocyte count <600/microL and/or <8 percent of the total white blood cell count | ||
| When applied to an initial group of 5141 patients with advanced Hodgkin lymphoma treated prior to 1992 with combination chemotherapy with or without radiation therapy, five-year overall survival (OS) and freedom from progression (FFP) rates according to score were as follows[1]: | ||
| Score | Five-year FFP, percent | Five-year OS, percent |
| 0 | 84 | 89 |
| 1 | 77 | 90 |
| 2 | 67 | 81 |
| 3 | 60 | 78 |
| 4 | 51 | 61 |
| 5 or more | 42 | 56 |
| When applied to 740 patients with advanced Hodgkin lymphoma treated with curative intent with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) from 1980 to 2010, five-year OS and FFP rates according to score were as follows[2]: | ||
| Score | Five-year FFP, percent | Five-year OS, percent |
| 0 | 88 | 98 |
| 1 | 84 | 97 |
| 2 | 80 | 91 |
| 3 | 74 | 88 |
| 4 | 67 | 85 |
| 5 or more | 62 | 67 |
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