Benign macrofollicular thyroid lesion: Findings on fine-needle aspirate

Low-power view of a fine-needle aspirate of a thyroid nodule showing an intact macrofollicle (a) and a macrofollicle that has been broken apart by the biopsy forming a flat sheet (b). At this power, the cells appear uniform in size and are not crowded. Not shown, but commonly present in macrofollicular lesions are areas of cystic degeneration, cellular debris, and hemosiderin-laden macrophages.