CDC evaluation of patients for smallpox

Major criteria:

Febrile prodrome: Occurring one to four days before rash onset: Fever ≥101°F (38.3°C) and at least one of the following: Prostration, headache, backache, chills, vomiting or severe abdominal pain.
Classic smallpox lesions: Deep-seated, firm/hard, round, well-circumscribed vesicles or pustules; as they evolve, lesions may become umbilicated or confluent.
Lesions in same stage of development: On any one part of the body (eg, the face, or arm) all the lesions are in the same stage of development (ie, all are vesicles, or all are pustules).

Minor criteria:

Centrifugal distribution: Greatest concentration of lesions on face and distal extremities.
First lesions on the oral mucosa/palate, face, or forearms.
Patient appears toxic or moribund.
Slow evolution: Lesions evolve from macules to papules to pustules over days (each stage lasts one to two days).
Lesions on the palms and soles.

CDC: United States Centers for Disease Control and Prevention.

Adapted from: United States Centers for Disease Control and Prevention. Smallpox: Evaluating Patients for Smallpox: Acute, Generalized Vesicular or Pustular Rash Illness Protocol. Available at: https://www.cdc.gov/smallpox/clinicians/algorithm-protocol.html (Accessed on July 19, 2018).

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CDC evaluation of patients for smallpox