Clinical and laboratory findings that can help distinguish Diamond-Blackfan anemia from transient erythroblastopenia of childhood

	Diamond-Blackfan anemia	Transient erythroblastopenia of childhood
Age	Classically presents in infancy	Presents at age 1 to 4 years
Preceding viral illness	No	Yes
Nonhematologic abnormalities	Approximately 50% have associated congenital abnormalities (eg, craniofacial abnormalities, thumb anomalies), growth failure, and/or developmental delays	Absent
Laboratory findings
Type of anemia	Usually macrocytic	Usually normocytic*
Reticulocyte count	Low	Low
Hemoglobin F	Increased	Normal
eADA activity	Elevated	Normal
Course	Progressive anemia with most patients requiring prolonged transfusion support or steroid therapy	Spontaneous recovery within weeks to months

eADA: erythrocyte adenosine deaminase.
* The mean corpuscular volume may be slightly elevated in patients with transient erythroblastopenia of childhood during recovery due to an increased number of reticulocytes.

Graphic 76264 Version 13.0

خرید پکیج

Clinical and laboratory findings that can help distinguish Diamond-Blackfan anemia from transient erythroblastopenia of childhood