Characteristics and differentiation of infusion reactions to chemotherapy

Symptoms and signs of mast cell/basophil-mediated infusion reactions	Symptoms and signs of cytokine-mediated infusion reactions
Flushing	Flushing
Itching	Itching
Urticaria and/or angioedema	Rash (various)
Dyspnea or chest tightness	Dyspnea or chest discomfort
Tongue, uvula, laryngeal edema, stridor	Rarely pulmonary infiltrates
Hypoxemia	Hypoxemia
Cough, wheeze	Nausea, vomiting and/or diarrhea
Nausea, vomiting, abdominal cramping and/or diarrhea	Back or abdominal pain
Hypotension, tachycardia (rarely bradycardia)	Alterations in heart rate or blood pressure
Sense of impending doom, dizziness and/or syncope	Dizziness and/or syncope
Fever (rare)	Fever

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