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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Results of TNF-based isolated limb perfusion for unresectable extremity soft tissue sarcoma

Results of TNF-based isolated limb perfusion for unresectable extremity soft tissue sarcoma
Author;
year		 n Treatment Response rate,
percent		 Limb salvage,
percent		 Overall survival,
percent		 Local recurrence,
percent
Complete Partial
Multicenter studies
Eggermont A; 1996 55 TNF+IFN+M 18 64 84 64 (two-year) NR
Eggermont A; 1996 186 TNF±IFN+M 18 57 82 NR 22
Eggermont A; 1999 246 TNF±IFN+M 28* 47 71 NR NR
Single center studies
Gutman M; 1997 35 TNF±IFN+M 37 54 85 NR 18
Olieman A; 1998 34 TNF±IFN+M 35 59 85 NR 26
LeJeune F; 2000 22 TNF±IFN+M 18 64 77 NR 45
Noorda E; 2003 49 TNF±IFN+M 8 55 58 48 (five-year) 13
Grunhagen D; 2005 64Δ TNF±IFN+M 42 45 82 39 (five-year) 45 (two-year)
Lans T; 2005 29◊ TNF±IFN+M 20 50 65 50 (five-year) 31 (two-year)
Bonvalot S; 2005§ 100 TNF+M 49¥ 17 87 82 (two-year) 24 (two-year)
Grunhagen D; 2006 217 TNF±IFN+M 18 51 87 49 (five-year) 26
Hayes A; 2007 16 TNF+M 20 33 75 NR 71
Pennacchioli E; 2007 88 Dox+M±TNF‡ 28 52 83 47 (five-year) 27 (five-year)
Van Ginkel R; 2007 73 TNF±IFN+M 25 69 61 59 (five-year) 10 (five-year)
Bonvalot S; 2009§ 100 TNF+M 30¥ 49 87 89 (three-year) 18 (three-year)
DiFilippo F; 2009 75 TNF+Dox 34 48 84 62 (five-year) 21
Deroose J; 2011 208 TNF+M 18 53 81

42 (five-year)

33 (ten-year)		 30
Deroose J; 2012 29† TNF+M 33 38 87 72 (three-year) 32
Olofsson R; 2012 54** TNF+M 21 50 76 44 (five-year) 37
TNF: tumor necrosis factor; IFN: interferon; M: melphalan; NR: not reported; Dox: doxorubicin.
* Complete response based on a complete necrosis histologically.
¶ Disease-specific survival.
Δ Multiple tumors in extremity.
◊ Previously irradiated field.
§ Lower dose TNF.
¥ Complete response determined radiographically.
‡ 51 treated with TNF, 37 with non-TNF isolated limb perfusion.
† All patients with soft tissue sarcoma in the distal parts of the limb.
** All candidates for amputation.
Graphic 76912 Version 9.0

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