Cytotoxic chemotherapy agents associated with radiation enhancement and radiation recall

Radiation enhancement

Bleomycin

Dactinomycin

Doxorubicin

Fluorouracil with and without cisplatin

Hydroxyurea

Mercaptopurine

Methotrexate

Paclitaxel

Gemcitabine

Chlorambucil

Capecitabine

Radiation recall

Arsenic trioxide

Bleomycin

Capecitabine

Cyclophosphamide

Cytarabine

Dactinomycin

Daunorubicin

Docetaxel

Doxorubicin (free and liposomal)

Etoposide

Fluorouracil

Gemcitabine

Hydroxyurea

Idarubicin

Lomustine

Melphalan

Methotrexate

Paclitaxel

Pemetrexed

Tamoxifen

Vinblastine

* Localized reactions typically involving areas of occluded skin (ifosfamide, topical carmustine, docetaxel, thiotepa) or the infusion site.

Data from:

Susser WS, Whitaker-Worth DL, Grant-Kels JM. Mucucutaneous reactions to chemotherapy. J Am Acad Dermatol 1999; 40:367.
Alley E, Green R, Schuchter L. Cutaneous toxicities of cancer therapy. Curr Opin Oncol 2002; 14:212.
Keung YK, Lyerly ES, Powell BL. Radiation recall phenomenon associated with arsenic trioxide. Leukemia 2003; 17:1417.

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