Molecular classification of colorectal carcinoma

	Chromosomal instability pathway (APC)	Mismatch repair pathway	Serrated pathway
	Hereditary (FAP) and sporadic	Hereditary	Hereditary	Sporadic
CIMP status	Negative	Negative	High	High
MSI status	MSS	MSI-H	MSI-H	MSI-L
Chromosomal instability	+++	---	---	---
KRAS mutation	+++	+/-	---	---
BRAF mutation	---	---	+++	+++
MLH1 status	Normal	Mutation	Methylated	Partial methylation

CIMP: CpG island methylator phenotype; MSS: microsatellite stability; MSI: microsatellite instability; MSI-H: high-level microsatellite instability; MSI-L: low-level microsatellite instability; +++: present; +/-: might or might not be present; ---: absent.

Graphic 77353 Version 5.0

خرید پکیج

Molecular classification of colorectal carcinoma