Prostate cancer and prominent nucleoli

High-power micrograph of a H&E-stained tissue section of a prostate gland adenocarcinoma following a short course of neoadjuvant hormone therapy (depot leuprolide acetate [panel A]); high-power photomicrograph of an H&E-stained prostate adenocarcinoma not previously treated with hormone therapy (panel B). The treated tumor cells have atrophic changes and cytoplasmic vacuolations, and the infiltrating patterns of the cells are retained, but the degree of nuclear atypia of the tumor cells, including the presence of prominent nucleoli, is reduced compared with untreated prostate cancer (panel B), in which the tumor cells have prominent nucleoli and amphophilic cytoplasm (arrows).