Indications for liver biopsy

Diagnosis, grading, and staging of alcoholic liver disease, nonalcoholic steatohepatitis, and autoimmune hepatitis

Grading and staging of chronic hepatitis B and C*

Diagnosis of:

Hemochromatosis (quantitative estimation of hepatic iron)
Wilson disease (quantitative hepatic copper)
Focal liver lesions

Evaluation of:

Cholestatic liver disease: primary biliary cholangitis, primary sclerosing cholangitis
Abnormal liver biochemical tests in a patient with a negative or inconclusive serologic work-up
Treatment efficacy
Side effects of treatment regimens (such as methotrexate for rheumatoid arthritis)
Post-liver transplant by protocol or for evaluation of abnormal liver biochemical tests
Donor liver
Fever of unknown origin

* Because of the development of newer hepatitis C treatments that are effective and tolerable, staging of liver disease prior to hepatitis C treatment may not be necessary. Refer to UpToDate topics on the treatment of hepatitis C for details.

Adapted from: Bravo AA, Sheth SG, Chopra S. Liver biopsy. N Engl J Med 2001; 344:495.

Graphic 77571 Version 8.0

خرید پکیج

Indications for liver biopsy