King's College Hospital criteria for liver transplantation in acute liver failure

Acetaminophen-induced disease

Arterial pH <7.3 (irrespective of the grade of encephalopathy)

Grade III or IV encephalopathy AND

Prothrombin time >100 seconds AND

Serum creatinine >3.4mg/dL (301 µmol/L)

All other causes of acute liver failure

Prothrombin time >100 seconds (irrespective of the grade of encephalopathy)

Any three of the following variables (irrespective of the grade of encephalopathy)

1. Age <10 years or >40 years

2. Etiology: non-A, non-B hepatitis, halothane hepatitis, idiosyncratic drug reactions

3. Duration of jaundice before onset of encephalopathy >7 days

4. Prothrombin time >50 seconds

5. Serum bilirubin >18 mg/dL (308 µmol/L)

Kings_College_criteria.htm

Data from: O'Grady JG, Alexander GJM, Hayllar KM, et al. Gastroenterology 1989; 97:439.

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