Version July 2025
| Bleeding characteristics | Type of bleeding disorder | |
| Thrombocytopenia, platelet function disorders, and VWD* | Clotting factor deficiencies or inhibitors | |
| Major sites of bleeding | Mucocutaneous (mouth, nose, gastrointestinal tract, urinary tract, menorrhagia). | Deep tissue (joints, muscles) or soft tissue hematomas. |
| Petechiae | Common. | Uncommon. |
| Ecchymoses | Generally small and superficial. May be significant, depending upon the degree of thrombocytopenia. | May develop large ecchymoses. |
| Excessive bleeding after minor cuts | Yes. | Not usually. |
| Excessive bleeding with surgery or invasive procedures | Often immediate; severity is variable (no excess bleeding with mild thrombocytopenia, severe bleeding with certain platelet function disorders such as GT). | Often during the procedure. Individuals with factor XIII deficiency may experience delayed bleeding. |
GT: Glanzmann thrombasthenia; VWD: von Willebrand disease.
* In most individuals with VWD, bruising, mucocutaneous bleeding, and heavy menstrual bleeding are the most common manifestations. Joint and muscle bleeding are not typical but can be seen if factor VIII activity is severely reduced (eg, types 2N and 3 VWD, which are uncommon).
