Clinical features of bleeding disorders

Bleeding characteristics	Type of bleeding disorder
Bleeding characteristics	Thrombocytopenia or platelet function disorders	Clotting factor deficiencies or inhibitors
Major sites of bleeding	Mucocutaneous (mouth, nose, gastrointestinal tract, urinary tract, menorrhagia)	Deep tissue (joints, muscles) or soft tissue hematomas
Petechiae	Common	Uncommon
Ecchymoses	Generally small and superficial. May be significant, depending upon the degree of thrombocytopenia.	May develop large ecchymoses
Excessive bleeding after minor cuts	Yes	Not usually
Excessive bleeding with surgery or invasive procedures	Often immediate; severity is variable (no excess bleeding with mild thrombocytopenia, severe bleeding with certain platelet function disorders such as GT)	Often during the procedure. Individuals with factor XIII deficiency may experience delayed bleeding.

Individuals with mild disorders may not report significant bleeding. Refer to UpToDate for details of the evaluation of a suspected bleeding disorder and for diagnostic testing for specific disorders.

GT: Glanzmann thrombasthenia.

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Clinical features of bleeding disorders