Amiodarone toxicity

Amiodarone lung biopsy photomicrograph shows diffuse alveolar damage in a patient with amiodarone toxicity. Alveolar spaces contain histiocytes with finely vacuolated cytoplasm (arrow). Chronic interstitial pneumonia with fibrosis and organizing pneumonia have also been described in patients with amiodarone toxicity.

High-power photomicrograph shows alveoli containing capillaries within a narrow interstitium. The alveoli are lined with thin, elongated type I pneumocytes (arrow) and smaller numbers of cuboidal type II pneumocytes (dashed arrow).