Conventional cytotoxic chemotherapy agents causing acral erythema (hand-foot skin reaction)

Bleomycin

Capecitabine

Cisplatin

Cyclophosphamide

Cytarabine*

Daunorubicin

Docetaxel

Doxifluridine

Doxorubicin (particularly pegylated liposomal doxorubicin)

Etoposide

Fludarabine

Fluorouracil (infusional regimens)

Gemcitabine

Hydroxyurea

Idarubicin

Ixabepilone

Methotrexate

Mitotane

Paclitaxel

Tegafur

Thiotepa

Vinorelbine

* Particularly in patients receiving cytarabine plus an anthracycline for treatment of acute leukemia.

Data from:

Susser WS, Whitaker-Worth DL, Grant-Kels JM. Mucocutaneous reactions to chemotherapy. J Am Acad Dermatol 1999; 40:367.
Alley E, Green R, Schuchter L. Cutaneous toxicities of cancer therapy. Curr Opin Oncol 2002; 14:212.
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356:125.
Hoff PM, Valero V, Ibrahim N, et al. Hand-foot syndrome following prolonged infusion of high doses of vinorelbine. Cancer 1998; 82:965.

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