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Drug properties of monoamine oxidase inhibitor antidepressants and dosages in the elderly (refer to note)

Drug properties of monoamine oxidase inhibitor antidepressants and dosages in the elderly (refer to note)
Drug Starting dose Dose range for older adult
Isocarboxazid 10 mg every morning 10 to 40 mg per day in divided doses
Phenelzine 7.5 mg every morning 22.5 to 60 mg per day in three divided doses
Tranylcypromine 10 mg every morning 10 to 40 mg per day in divided doses
Selegiline (transdermal patch) 6 mg/24 hours applied once daily 6 to 12 mg/24 hours applied once daily
IMPORTANT NOTE: MAOIs are NOT first line antidepressant medications due to the dietary restrictions, drug-drug interactions and potentially severe side-effects. MAOIs are rarely used in medically ill or older adults except when previously initiated and tolerated in the patient who is treatment resistant to all other antidepressants. For specific drug interactions refer to the drug interaction program included with UpToDate. For additional information, refer to the separate topic on MAOIs for treating depressed adults.
MAOI: monoamine oxidase inhibitors.
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