NCI CTCAE v5.0 neurotoxicity

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Depressed level of consciousness	Decreased level of alertness	Sedation; slow response to stimuli; limiting instrumental ADL*	Difficult to arouse	Life-threatening consequences; coma; urgent intervention indicated	Death
Dysphasia	Awareness of receptive or expressive characteristics; not impairing ability to communicate	Moderate receptive or expressive characteristics; impairing ability to communicate spontaneously	Severe receptive or expressive characteristics; impairing ability to read, write, or communicate intelligibly		-
Edema cerebral			New onset; worsening from baseline	Life-threatening consequences; urgent intervention indicated	Death
Encephalopathy	Mild symptoms	Moderate symptoms; limiting instrumental ADL*	Severe symptoms; limiting self-care ADL*	Life-threatening consequences; urgent intervention indicated	Death
Headache	Mild pain	Moderate pain; limiting instrumental ADL*	Severe pain; limiting self-care ADL*		-
Paresthesia	Mild symptoms	Moderate symptoms; limiting instrumental ADL*	Severe symptoms; limiting self-care ADL*		-
Peripheral motor neuropathy	Asymptomatic; clinical or diagnostic observations only	Moderate symptoms; limiting instrumental ADL*	Severe symptoms; limiting self-care ADL*	Life-threatening consequences; urgent intervention indicated	Death
Peripheral sensory neuropathy	Asymptomatic	Moderate symptoms; limiting instrumental ADL*	Severe symptoms; limiting self-care ADL*	Life-threatening consequences; urgent intervention indicated	-
Seizure	Brief partial seizure and no loss of consciousness	Brief generalized seizure	New onset seizures (partial or generalized); multiple seizures despite medical intervention	Life-threatening consequences; prolonged repetitive seizures	Death
Tremor	Mild symptoms	Moderate symptoms; limiting instrumental ADL*	Severe symptoms; limiting self-care ADL*		-

Definitions are based on the CTCAE document:

Depressed level of consciousness is characterized by a decrease in ability to perceive and respond.
Dysphasia is characterized by impairment of verbal communication skills, often resulting from brain damage.
Edema cerebral is characterized by swelling due to an excessive accumulation of fluid in the brain.
Encephalopathy is characterized by a pathologic process involving the brain.
Headache is characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve.
Paresthesia is characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that are experienced in the absence of a stimulus.
Peripheral motor neuropathy is characterized by inflammation or degeneration of the peripheral motor nerves.
Peripheral sensory neuropathy is characterized by inflammation or degeneration of the peripheral sensory nerves.
Seizure is characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin.
Tremor is characterized by the uncontrolled shaking movement of the whole body or individual parts.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; ADL: activities of daily living.
* Instrumental ADLs include preparing meals, shopping, using the telephone, managing money. Self-care ADLs include bathing, dressing/undressing, using the toilet, taking medications, and not bedridden.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

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NCI CTCAE v5.0 neurotoxicity