Timing of prophylactic antibiotic administration and subsequent rates of SSIs

Time of administration*	Percent with SSI	Odds ratio^¶	95% CI
Early	3.8	4.3	1.8-10.4
Preoperative	0.6	1	-
Perioperative	1.4	2.1	0.6-7.4
Postoperative	3.3	5.8	2.4-13.8

SSI: surgical site infection.
* "Early" denotes 2 to 24 hours before incision, "preoperative" 0 to 2 hours before incision, "perioperative" within 3 hours after incision, and "postoperative" more than 3 hours after incision.
¶ Odds ratio determined by logistic-regression analysis.

Data from: Classen DC, Evans RS, Pestotnik SL, et al. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med 1992; 326:281.

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خرید پکیج

Timing of prophylactic antibiotic administration and subsequent rates of SSIs