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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Immunohistochemical schema for the differential diagnosis of spindle cell tumors of the gastrointestinal tract

Immunohistochemical schema for the differential diagnosis of spindle cell tumors of the gastrointestinal tract
Type CD117 DOG-1 PKC-theta CD34 SMA* S100 protein Desmin
GISTs +
(>95%)		 +
(97%)		 +
(72%)		 +
(60 to 70%)		 +/–
(30 to 40%)		 –
(5% +)		 Very rare
Leiomyoma – –   +
(10 to 15%)		 + – +
Leiomyosarcoma – – +
(10%)		 – + – +
Schwannoma – – +
(10%)		 – – + –
DOG-1: discovered on GIST-1; PKC-theta: protein kinase C theta; GISTs: gastrointestinal stromal tumors.
* Alpha smooth muscle actin.
Adapted from:
  1. Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Int J Surg Pathol 2002; 10:81.
  2. Miettinen M, Sobin LH, Sarlomo-Rikala M. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT). Mod Pathol 2000; 10:1134.
  3. Miettinen M, Wang ZF, Lasota J. DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol 2009; 33:1401.
  4. Duensing A, Joseph NE, Medeiros F, et al. Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs). Cancer Res 2004; 64:5127.
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