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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Preparation of rectal formulations of thionamides

Preparation of rectal formulations of thionamides
Methimazole
Suppository Dissolve 1200 mg methimazole in 12 mL of water, and add to 52 mL cocoa butter containing 2 drops of polysorbate (Span) 80. Stir mixture to form an emulsion, and pour into 2.6 mL suppository molds to cool.[1]
Propylthiouracil
Suppository Dissolve 200 mg of propylthiouracil in a polyethylene glycol base, and put into suppository tablets.
Retention enema

Dissolve 8 to 12 (50 mg) tablets of propylthiouracil in 90 mL of sterile water.

OR

Dissolve 8 (50 mg) tablets of propylthiouracil in 60 mL of mineral oil enema (eg, Fleet mineral oil) or in 60 mL of sodium phosphates enema solution* (eg, Fleet enema phospho-soda).[2]

For either enema preparation: Administer by Foley catheter inserted into the rectum, with balloon inflated to prevent leakage for 2-hour retention.
Additional information on preparation described in:
  • Nayak B, Burman K. Thyrotoxicosis and thyroid storm. Endocrinol Metab Clin North Am 2006; 35:663.
  • Yeung SC, Go R, Balasubramanyam A. Rectal administration of iodide and propylthiouracil in the treatment of thyroid storm. Thyroid 1995; 5:403.
  • Jongjaroenprasert W, Akarawut W, Chantasart D, et al. Rectal administration of propylthiouracil in hyperthyroid patients: comparison of suspension enema and suppository form. Thyroid 2002; 12:627.
* Avoid phosphate-containing rectal preparations in patients with kidney insufficiency or heart failure.
References:
  1. Nabil N, Miner DJ, Amatruda JM. Methimazole: an alternative route of administration. J Clin Endocrinol Metab 1982; 54:180.
  2. Walter RM Jr, Bartle WR. Rectal administration of propylthiouracil in the treatment of Graves' disease. Am J Med 1990; 88:69.
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